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Index > Protein center > Unc5c(Gene name) > Mouse
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  • Unc5c (Gene name),
  • Netrin receptor UNC5C (Protein name ),  UNC5C_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Unc5c(Rcm;Unc5h3);
    Protein name:
    Netrin receptor UNC5C;
    Alternative:
    Protein unc-5 homolog C;Protein unc-5 homolog 3;Rostral cerebellar malformation protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with the cytoplasmic part of DCC.
    Function:
    Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    931
    Sequence:
    50:
    MRKGLRATAA | RCGLGLGYLL | QMLVLPALAL | LSASGTGSAA | QDDEFFHELP | 
    100:
    ETFPSDPPEP | LPHFLIEPEE | AYIVKNKPVN | LYCKASPATQ | IYFKCNSEWV | 
    150:
    HQKDHVVDER | VDETSGLIVR | EVSIEISRQQ | VEELFGPEDY | WCQCVAWSSA | 
    200:
    GTTKSRKAYV | RIAYLRKTFE | QEPLGKEVSL | EQEVLLQCRP | PEGIPVAEVE | 
    250:
    WLKNEDIIDP | AEDRNFYITI | DHNLIIKQAR | LSDTANYTCV | AKNIVAKRKS | 
    300:
    TTATVIVYVN | GGWSTWTEWS | VCNSRCGRGY | QKRTRTCTNP | APLNGGAFCE | 
    350:
    GQSVQKIACT | TLCPVDGRWT | SWSKWSTCGT | ECTHWRRREC | TAPAPKNGGK | 
    400:
    DCDGLVLQSK | NCTDGLCMQA | APDSDDVALY | VGIVIAVTVC | LAITVVVALF | 
    450:
    VYRKNHRDFE | SDIIDSSALN | GGFQPVNIKA | ARQDLLAVPP | DLTSAAAMYR | 
    500:
    GPVYALHDVS | DKIPMTNSPI | LDPLPNLKIK | VYNSSGAVTP | QDDLAEFSSK | 
    550:
    LSPQMTQSLL | ENEALNLKNQ | SLARQTDPSC | TAFGTFNSLG | GHLIIPNSGV | 
    600:
    SLLIPAGAIP | QGRVYEMYVT | VHRKENMRPP | MEDSQTLLTP | VVSCGPPGAL | 
    650:
    LTRPVILTLH | HCADPSTEDW | KIQLKNQAVQ | GQWEDVVVVG | EENFTTPCYI | 
    700:
    QLDAEACHIL | TENLSTYALV | GQSTTKAAAK | RLKLAIFGPL | CCSSLEYSIR | 
    750:
    VYCLDDTQDA | LKEVLQLERQ | MGGQLLEEPK | ALHFKGSIHN | LRLSIHDIAH | 
    800:
    SLWKSKLLAK | YQEIPFYHIW | SGSQRNLHCT | FTLERLSLNT | VELVCKLCVR | 
    850:
    QVEGEGQIFQ | LNCTVSEEPT | GIDLPLLDPA | STITTVTGPS | AFSIPLPIRQ | 
    900:
    KLCSSLDAPQ | TRGHDWRMLA | HKLNLDRYLN | YFATKSSPTG | VILDLWEAQN | 
    931:
    FPDGNLSMLA | AVLEEMGRHE | TVVSLAAEGQ | Y
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Netrin receptor UNC5C
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    E7813h
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    ELISA Kit for Mouse Netrin receptor UNC5C
    MSDS:
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    ELISA Kit for Mouse Netrin receptor UNC5C
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    E7813m
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    Packing:
    96T
    ELISA Kit for Mouse Netrin receptor UNC5C
    Cat.:
    E7813r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Netrin receptor UNC5C
    Cat.:
    U7813r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Netrin receptor UNC5C
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Netrin receptor UNC5C
    Cat.:
    U7813h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Netrin receptor UNC5C
    Cat.:
    U7813m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Netrin receptor UNC5C
    Polyclonal Antibody for Mouse Netrin receptor UNC5C
    Cat.:
    P7813Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Netrin receptor UNC5C
    Cat.:
    P7813Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Netrin receptor UNC5C
    Monoclonal Antibody for Mouse Netrin receptor UNC5C
    Monoclonal Antibody for Mouse Netrin receptor UNC5C
    Monoclonal Antibody for Mouse Netrin receptor UNC5C
    Monoclonal Antibody for Mouse Netrin receptor UNC5C
    Protein for Mouse Netrin receptor UNC5C
    Protein for Mouse Netrin receptor UNC5C
    Protein for Mouse Netrin receptor UNC5C
    Protein for Mouse Netrin receptor UNC5C

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    References
    1. 1.
      "The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein."
      Ackerman S.L. , Kozak L.P. , Przyborski S.A. , Rund L.A. , Boyer B.B. , Knowles B.B.
      Nature386:838-842(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;DISEASE;TISSUE SPECIFICITY
      strain: C57B6/SJL.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Testis.
    3. 3.
      "Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary."
      Przyborski S.A. , Knowles B.B. , Ackerman S.L.
      Development125:41-50(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    4. 4.
      "A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion."
      Hong K. , Hinck L. , Nishiyama M. , Poo M.-M. , Tessier-Lavigne M. , Stein E.
      Cell97:927-941(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DCC
    5. 5.
      "Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain."
      Tong J. , Killeen M. , Steven R. , Binns K.L. , Culotti J. , Pawson T.
      J. Biol. Chem.276:40917-40925(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-568;MUTAGENESIS OF TYR-568
    6. 6.
      "The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons."
      Finger J.H. , Bronson R.T. , Harris B. , Johnson K. , Przyborski S.A. , Ackerman S.L.
      J. Neurosci.22:10346-10356(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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